Dr. Sreenivasa Reddy completed his doctoral degree in Biochemistry in 2009, focusing on identifying novel therapeutics derived from natural sources for insulin resistance. Subsequently, his postdoctoral research centered around exploring the involvement of the Ubiquitin Proteasome System and Endoplasmic Reticulum (ER) Stress in diabetes and obesity-related complications. He worked on proteasome and ER stress inhibitors in diabetic retinopathy, muscle wastage, and neurodegeneration.
Currently, Dr. Reddy's research is predominantly oriented towards Nutrition and dietary-based interventional approaches aimed at preventing and treating age-related and lifestyle-related diseases. The research has a specific focus on understanding the role of nutrition in addressing conditions such as diabetes and obesity. Furthermore, his work involves a comprehensive investigation into the impact and underlying molecular mechanisms of deficiencies in vitamins and minerals on overall health and the development of diseases. This research aims to contribute to a deeper understanding of the intricate relationship between nutrition and health outcomes.

List of selected publications in last 10 years

1. Kalahasti KK, Kumar CU, Nagaraju M, Petrash JM, Reddy SS, Reddy GB. Mitigation of lens opacification by a functional food in a diabetic rodent model. Chem Biol Interact. 2024 Feb 25;390:110889. PMID: 38272248
2. Savitikadi P, Palika R, Pullakhandam R, Reddy GB, Reddy SS. Dietary zinc inadequacy affects neurotrophic factors and proteostasis in the rat brain. Nutr Res. 2023 Aug;116:80-88. PMID: 37421933
3. Nagaraju M, Kalahasti KK, Reddy KP, Addi UR, Satyavani M, Reddy GB, Reddy SS. Anti-inflammatory potential of turmeric, amla, and black pepper mixture against sepsis-induced acute lung injury in rats. J Food Sci Technol. 2023 Jan;60(1):252-261. PMID: 36349282.
4. Kumar CU, Reddy SS, Suryanarayana P, Patil MA, Chary PM, Kumar PU, Reddy GB. Protective effect of cinnamon on diabetic cardiomyopathy in nicotinamide-streptozotocin induced diabetic rat model. J Diabetes Metab Disord. 2022 Jan 21;21(1):141-150. PMID: 35673461.
5. Reddy SS, Addi UR, Pullakhandam R, Reddy GB. Dietary zinc deficiency disrupts skeletal muscle proteostasis and mitochondrial biology in rats. Nutrition. 2022 Jun;98:111625. PMID: 35439650.
6. Padakandla SR, Das T, Sai Prashanthi G, Angadi KK, Reddy SS, Reddy GB, Shivaji S. Gut mycobiome dysbiosis in rats showing retinal changes indicative of diabetic retinopathy. PLoS One. 2022 Apr 19;17(4):e0267080. PMID: 35439275.
7. Reddy Addi U, Jakhotia S, Reddy SS, Reddy GB. Age-related neuronal damage by advanced glycation end products through altered proteostasis. Chem Biol Interact. 2022 Mar 1;355:109840. PMID: 35104490.
8. Srinivasarao DA, Reddy SS, Reddy GB, Katti DS. Simultaneous amelioration of diabetic ocular complications in lens and retinal tissues using a non-invasive drug delivery system. Int J Pharm. 2021 Oct 25;608:121045. PMID: 34481006.
9. Padakandla SR, Das T, Sai Prashanthi G, Angadi KK, Reddy SS, Reddy GB, Shivaji S. Dysbiosis in the Gut Microbiome in Streptozotocin-Induced Diabetes Rats and Follow-Up During Retinal Changes. Invest Ophthalmol Vis Sci. 2021 Aug 2;62(10):31. PMID: 34431974.
10. Reddy SS, Prabhakar YK, Kumar CU, Reddy PY, Reddy GB. Effect of vitamin B12 supplementation on retinal lesions in diabetic rats. Mol Vis. 2020 Apr 24;26:311-325. PMID: 32355441
11. Godisela KK, Reddy SS, Reddy PY, Kumar CU, Reddy VS, Ayyagari R, Reddy GB. Role of sorbitol-mediated cellular stress response in obesity-associated retinal degeneration. Arch Biochem Biophys. 2020 Jan 15;679:108207. PMID: 31760123
12. Srinivasarao DA, Reddy SS, Reddy GB, Katti DS. Spatio-temporal control on the delivery of triamcinolone acetonide using polymeric nanoparticles reduces steroid induced cataract. Int J Pharm. 2019 Sep 10;568:118474. PMID: 31279055
13. Reddy SS, Shruthi K, Joy D, Reddy GB. 4-PBA prevents diabetic muscle atrophy in rats by modulating ER stress response and ubiquitin-proteasome system. Chem Biol Interact. 2019 Jun 1;306:70-77. PMID: 30980806
14. Shruthi K, Reddy SS, Chitra PS, Reddy GB. Ubiquitin-proteasome system and ER stress in the brain of diabetic rats. J Cell Biochem. 2019 Apr;120(4):5962-5973. PMID: 30317658
15. Gopalakrishnan S, Ediga HH, Reddy SS, Reddy GB, Ismail A. Procyanidin-B2 enriched fraction of cinnamon acts as a proteasome inhibitor and anti-proliferative agent in human prostate cancer cells. IUBMB Life. 2018 May;70(5):445-457. PMID: 29537730
16. Reddy SS, Shruthi K, Prabhakar YK, Sailaja G, Reddy GB. Implication of altered ubiquitin-proteasome system and ER stress in the muscle atrophy of diabetic rats. Arch Biochem Biophys. 2018 Feb 1;639:16-25. PMID: 29277369
17. Shruthi K, Reddy SS, Reddy GB. Ubiquitin-proteasome system and ER stress in the retina of diabetic rats. Arch Biochem Biophys. 2017 Aug 1;627:10-20. PMID: 28606465
18. Godisela KK, Reddy SS, Kumar CU, Saravanan N, Reddy PY, Jablonski MM, Ayyagari R, Reddy GB. Impact of obesity with impaired glucose tolerance on retinal degeneration in a rat model of metabolic syndrome. Mol Vis. 2017 Apr 14;23:263-274. PMID: 28465658
19. Shruthi K, Reddy SS, Reddy PY, Shivalingam P, Harishankar N, Reddy GB. Amelioration of neuronal cell death in a spontaneous obese rat model by dietary restriction through modulation of ubiquitin proteasome system. J Nutr Biochem. 2016 Jul;33:73-81. PMID: 27260470
20. Reddy SS, Shruthi K, Reddy VS, Raghu G, Suryanarayana P, Giridharan NV, Reddy GB. Altered ubiquitin-proteasome system leads to neuronal cell death in a spontaneous obese rat model. Biochim Biophys Acta. 2014 Sep;1840(9):2924-34. PMID: 24949983